Potential benefits of late reperfusion of infarcted myocardium. The open artery hypothesis.
نویسندگان
چکیده
117. Cannon CP, McCabe CH, Henry TD, Rogers WJ, Schweiger M, Gibson RS, Anderson JL, WilliamsDO, Braunwald E, for theTIMI 5 Investigators. Hirudinreduces reocclusion compared to heparin following thrombolysis in acutemyocardial infarction: results of the TIMI-5 trial.J AmColl Cardiol. 1993;21:136a.
منابع مشابه
The Open Artery Hypothesis
There is considerable clinical and experimental evidence of the benefit of late reperfusion of infarct-related arteries, referred to as the open artery hypothesis, in patients with acute myocardial infarction who presented too late to salvage at-risk ischemic myocardium. In addition to myocardial salvage, reperfusion of the infarct-related artery prevents infarct expansion, reduces development ...
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Experiments were performed to test the hypothesis that a reduction in the space constant contributes to slow conduction in the infarcted myocardium of dogs 5-8 days after coronary artery occlusion and reperfusion. Standard microelectrode techniques were used to measure action potential characteristics and conduction velocity parallel to fiber orientation in normal and infarcted ventricular epic...
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Single photon-emission tomography (SPECT) and indium 111-labeled monoclonal antimyosin Fab fragments were used to measure myocardial infarct size in 12 dogs, six subjected to balloon catheter-induced coronary artery occlusion for 6 hr (late reperfusion) and six subjected to occlusion with reperfusion at 2 hr (early reperfusion). Tomographic imaging was performed 24 hr after the intravenous inje...
متن کاملUltrasound strain imaging of altered myocardial stiffness: stunned versus infarcted reperfused myocardium.
BACKGROUND In this study we evaluate the diastolic deformation of ischemic/reperfused myocardium and relate this deformation to tissue elastic properties. METHODS AND RESULTS Farm pigs were subjected to left anterior descending coronary artery occlusion followed by reperfusion to create either stunning (n=12) or transmural myocardial infarction (n=12). Ultrasound-derived radial strain rates (...
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OBJECTIVE Evasins (chemokine-binding proteins) have been shown to selectively neutralize chemokine bioactivity. We investigated the potential benefits of Evasin-3 on mouse myocardial ischemia/reperfusion injury. METHODS AND RESULTS In vivo and ex vivo (Langendorff model) left coronary artery ligature was performed in C57Bl/6 mice. Coronary occlusion was maintained for 30 minutes, followed by ...
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ورودعنوان ژورنال:
- Circulation
دوره 88 5 Pt 1 شماره
صفحات -
تاریخ انتشار 1993